Stoops William W, Lile Joshua A, Glaser Paul E A, Rush Craig R
Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, 40536-0086, USA.
Drug Alcohol Depend. 2006 Sep 15;84(2):206-9. doi: 10.1016/j.drugalcdep.2006.02.004. Epub 2006 Mar 15.
Despite increased reports of amphetamine abuse and dependence, a putative pharmacotherapy has yet to be identified. In a previous study from our laboratory, 20 mg aripiprazole, an atypical antipsychotic that has partial agonist activity at D(2) receptors, attenuated many of the behavioral effects of d-amphetamine. Aripiprazole (20 mg) also impaired performance on a computerized version of the DSST when administered alone, indicating that the attenuation observed may have been functional as opposed to receptor mediated. The present experiment was conducted to determine whether a lower dose of aripiprazole (10 mg) could acutely attenuate the discriminative-stimulus, subject-rated, and physiological effects of d-amphetamine (2.5-15 mg) without impairing performance as measured with a computerized version of the DSST. The results of the present experiment indicate that 10 mg aripiprazole attenuated some abuse-related behavioral effects of d-amphetamine and was generally devoid of effects, including significant performance impairment, when administered alone. These findings suggest that 10 mg aripiprazole would be a reasonable starting dose for the treatment of stimulant abuse and dependence. Future research should examine the effects of chronic aripiprazole administration in combination with methamphetamine or cocaine.
尽管苯丙胺滥用和依赖的报告有所增加，但尚未确定一种假定的药物疗法。在我们实验室之前的一项研究中，20毫克阿立哌唑（一种在D(2)受体上具有部分激动剂活性的非典型抗精神病药物）减弱了右旋苯丙胺的许多行为效应。单独给药时，阿立哌唑（20毫克）也会损害计算机化版本的数字符号替换测验（DSST）的表现，这表明观察到的减弱可能是功能性的，而非受体介导的。进行本实验是为了确定较低剂量的阿立哌唑（10毫克）是否能在不损害计算机化版本的DSST所测量的表现的情况下，急性减弱右旋苯丙胺（2.5 - 15毫克）的辨别刺激、受试者评分和生理效应。本实验结果表明，10毫克阿立哌唑减弱了右旋苯丙胺一些与滥用相关的行为效应，并且单独给药时通常没有影响，包括显著的表现损害。这些发现表明，10毫克阿立哌唑将是治疗兴奋剂滥用和依赖的合理起始剂量。未来的研究应考察长期给予阿立哌唑与甲基苯丙胺或可卡因联合使用的效果。
