Würzner R, Tokunaga K, Nitze R, Götze O, Lachmann P J
Molecular Immunopathology Unit, Medical Research Council Centre, Cambridge, UK.
Exp Clin Immunogenet. 1991;8(3):177-83.
Two complement C7 protein polymorphisms exist. One is determined by isoelectric focussing whereas the other is determined by the reaction pattern of a monoclonal C7-allospecific antibody in an ELISA assay. C7 concentrations quantitated by an ELISA based on polyclonal C7-specific IgG and data from functional haemolytic assays were compared with the allotypes of both C7 protein polymorphisms. Testing a randomly selected Japanese population revealed that not only C73 but also C7N is a hypomorphic allele. However, no significant disease association of C7N or C7M was found in studies of hospitalized patients.