Stevens Edward L, Twenhafel Nancy A, MacLarty Anne M, Kreiselmeier Norman
Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
J Am Assoc Lab Anim Sci. 2007 Nov;46(6):65-9.
We describe severe necrohemorrhagic cystitis in a female rhesus macaque and a female cynomolgus macaque due to colonization of the urinary bladder by Corynebacterium sp. Clinically, both macaques presented with perineal bleeding and depression and, despite extensive and prolonged treatment, succumbed to the disease. At necropsy, the contents of the urinary bladders in both cases were hemorrhagic to greenish black, and the bladder mucosa was necrotic. The major microscopic finding in each case was transmural necrohemorrhagic cystitis, with vasculitis, fibrin thrombi, and myriad gram-positive coryneform bacilli. Corynebacterium renale, Streptococcus acidominimus, and S. oralis were cultured from the urinary bladder of the rhesus macaque, and a nondiphtheritic Corynebacterium was cultured from the urinary bladder of the cynomolgus macaque. Neither animal had any other noteworthy pathologic lesions unrelated to bacterial cystitis. Corynebacterial necrohemorrhagic cystitis therefore was determined to be the cause of death in both animals. To our knowledge, this is the fi rst report of corynebacterial cystitis in nonhuman primates.
我们描述了一只雌性恒河猴和一只雌性食蟹猴因膀胱被棒状杆菌属定殖而发生的严重坏死性出血性膀胱炎。临床上，两只猕猴均出现会阴出血和精神沉郁，尽管接受了广泛且长期的治疗，但仍死于该病。尸检时，两例病例的膀胱内容物均为出血性至绿黑色，膀胱黏膜坏死。每例病例的主要微观发现是透壁坏死性出血性膀胱炎，伴有血管炎、纤维蛋白血栓和大量革兰氏阳性棒状杆菌。从恒河猴的膀胱中培养出了肾棒状杆菌、嗜酸微球菌和口腔链球菌，从食蟹猴的膀胱中培养出了一种非白喉棒状杆菌。两只动物均没有与细菌性膀胱炎无关的其他值得注意的病理病变。因此，棒状杆菌坏死性出血性膀胱炎被确定为两只动物的死因。据我们所知，这是关于非人灵长类动物棒状杆菌膀胱炎的首次报道。
