Curry Chelsea R, Saluja Karan, Das Sanchita, Thakral Beenu, Dangle Pankaj, Keeler Thomas C, Watkin William G
Department of Pathology and Laboratory Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois and NorthShore University HealthSystem, Evanston, Illinois.
Department of Pathology and Laboratory Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois and NorthShore University HealthSystem, Evanston, Illinois
Lab Med. 2015 Spring;46(2):136-9. doi: 10.1309/LMXQP557EINXBXIF.
Encrusted cystitis is a rare condition characterized by encrustation of the bladder mucosa with associated chronic inflammation induced by urea-splitting bacterial infection--most commonly, Corynebacterium urealyticum. Moreover, it usually occurs in immunocompromised patients, especially recipients of renal transplants or patients with a history of previous urological procedures. Due to the rarity of the entity and the slow growth of Corynebacterium species, appropriate treatment is often delayed due to difficulties in diagnosis and resistance to numerous antibiotics. We report a case of encrusted cystitis caused by Corynebacterium glucuronolyticum, another urea-splitting microbe, in a 57-year-old previously healthy Caucasian man with no known predisposing factors. The timely diagnosis and management in this otherwise healthy patient was facilitated by characteristic imaging, cystoscopy, and histologic findings confirmed by results of prolonged urine cultures and 16S ribosomal RNA (rRNA) gene sequencing of the microbe.
结痂性膀胱炎是一种罕见病症，其特征为膀胱黏膜结痂，并伴有由分解尿素的细菌感染（最常见的是解脲棒状杆菌）引起的慢性炎症。此外，它通常发生在免疫功能低下的患者中，尤其是肾移植受者或有既往泌尿外科手术史的患者。由于该病症罕见且棒状杆菌生长缓慢，诊断困难且对多种抗生素耐药，因此适当的治疗常常延迟。我们报告一例由另一种分解尿素的微生物——解葡萄糖醛酸棒状杆菌引起的结痂性膀胱炎病例，患者为一名57岁、既往健康、无已知易感因素的白种男性。通过特征性影像学检查、膀胱镜检查以及延长尿液培养结果和该微生物的16S核糖体RNA（rRNA）基因测序证实的组织学发现，促成了对这名原本健康患者的及时诊断和治疗。
