Kawahara R, Takeshita H, Komatsu K, Ito K, Tanaka Y
Department of Neuro-psychiatry, Faculty of Medicine, Tottori University, Yonago, Japan.
No To Shinkei. 1991 Oct;43(10):931-7.
We have examined the correlation of dementia severity and brainstem auditory evoked potentials. The subjects were 80 patients with dementia (20 males, 60 females) whose mean age was 80.7 years. Normal controls were 9 elderly subjects (2 males, 7 females) whose mean age was 80.4 years. The following parameters were measured: peak latencies (I, III and V), interpeak latencies (I-III, III-V and I-V) and interaural latency differences (V PLDs and I-V IPLDs). As for clinical items and sex differences; (1) There were sex differences recognized between peak latency of III and V, interpeak latency of III-V and I-V. (2) There was a significant difference in interaural differences of V PL Ds between vascular dementia and degenerative dementia (dementia of the Alzheimer's type and Parkinson's disease). Duration of illness had no correlation with latencies of BAEPs. Dividing the patients into three groups according to the severity of dementia which are mild, moderate and severe, (3) peak latency of III, V and interpeak latency of I-III, III-V, I-V and interaural latency differences of V PL Ds prolonged significantly with the increasing severity of dementia. From these results, it is suggested that brainstem dysfunction progresses with the increasing severity of the dementia.
我们研究了痴呆严重程度与脑干听觉诱发电位之间的相关性。研究对象为80例痴呆患者（男性20例，女性60例），平均年龄80.7岁。正常对照组为9名老年受试者（男性2例，女性7例），平均年龄80.4岁。测量了以下参数：峰潜伏期（I、III和V）、峰间潜伏期（I-III、III-V和I-V）以及双耳潜伏期差异（V PLDs和I-V IPLDs）。至于临床项目和性别差异：（1）在III和V的峰潜伏期、III-V和I-V的峰间潜伏期之间存在性别差异。（2）血管性痴呆与退行性痴呆（阿尔茨海默病型痴呆和帕金森病）之间在V PLDs的双耳差异方面存在显著差异。病程与BAEPs的潜伏期无相关性。根据痴呆严重程度将患者分为轻度、中度和重度三组，（3）随着痴呆严重程度的增加，III、V的峰潜伏期以及I-III、III-V、I-V的峰间潜伏期和V PLDs的双耳潜伏期差异显著延长。从这些结果来看，提示脑干功能障碍随着痴呆严重程度的增加而进展。
