Ito J
Department of Central Clinical Laboratory, Kyoto University.
Rinsho Byori. 1991 Aug;39(8):859-64.
To study the effects of aging and gender differences of ERP components, auditory ERPs were recorded in 106 healthy subjects. Forty-three patients with dementia of the Alzheimer type and 24 patients with vascular dementia were also studied. In healthy subjects, there was a significant positive linear correlation between P300 latency and age, with P300 latency increasing at the rate of 1.5 msec/year. Neither N100 nor P200 component was correlated with age. The amplitudes of N100, P200 and P300 components in females were slightly larger than those in males, but the differences were not significant. Not only P300 latencies but also P200 latencies were significantly different in healthy subjects, patients with dementia of the Alzheimer type and those with vascular dementia. In 74.4% of patients with dementia of the Alzheimer type and 62.5% of those with vascular dementia, the P300 latency was over 2 SE above the age-estimated regression line. The difference of the P300 latency prolongation may have resulted from the severity of dementia but not from the etiology of dementia.
为研究事件相关电位（ERP）成分的衰老及性别差异影响，对106名健康受试者记录了听觉ERP。还研究了43例阿尔茨海默型痴呆患者和24例血管性痴呆患者。在健康受试者中，P300潜伏期与年龄呈显著正线性相关，P300潜伏期以每年1.5毫秒的速度增加。N100和P200成分均与年龄无关。女性的N100、P200和P300成分波幅略大于男性，但差异不显著。健康受试者、阿尔茨海默型痴呆患者和血管性痴呆患者不仅P300潜伏期，而且P200潜伏期也存在显著差异。在74.4%的阿尔茨海默型痴呆患者和62.5%的血管性痴呆患者中，P300潜伏期超过年龄估计回归线2个标准误以上。P300潜伏期延长的差异可能是由痴呆的严重程度导致的，而非痴呆的病因。
