Kovas Yulia, Haworth Claire M A, Dale Philip S, Plomin Robert
Goldsmiths College, University of London and SGDP Centre, Institute of Psychiatry.
Monogr Soc Res Child Dev. 2007;72(3):vii, 1-144. doi: 10.1111/j.1540-5834.2007.00439.x.
Despite the importance of learning abilities and disabilities in education and child development, little is known about their genetic and environmental origins in the early school years. We report results for English (which includes reading, writing, and speaking), mathematics, and science as well as general cognitive ability in a large and representative sample of U.K. twins studied at 7, 9, and 10 years of age. Although preliminary reports of some of these data have been published, the purpose of this monograph is to present new univariate, multivariate, and longitudinal analyses that systematically examine genetic and environmental influences for the entire sample at all ages for all measures for both the low extremes (disabilities) and the entire sample (abilities). English, mathematics, and science yielded similarly high heritabilities and modest shared environmental influences at 7, 9, and 10 years despite major changes in content across these years. We draw three conclusions that go beyond estimating heritability. First, the abnormal is normal: Low performance is the quantitative extreme of the same genetic and environmental influences that operate throughout the normal distribution. Second, continuity is genetic and change is environmental: Longitudinal analyses suggest that age-to-age stability is primarily mediated genetically, whereas the environment contributes to change from age to age. Third, genes are generalists and environments are specialists: Multivariate analyses indicate that genes largely contribute to similarity in performance within and between the three domains--and with general cognitive ability--whereas the environment contributes to differences in performance. These conclusions have far-reaching implications for education and child development as well as for molecular genetics and neuroscience.
尽管学习能力和学习障碍在教育及儿童发展中至关重要,但对于其在小学早期阶段的遗传和环境根源,我们却知之甚少。我们报告了对英国7岁、9岁和10岁双胞胎这一大型代表性样本在英语(包括阅读、写作和口语)、数学、科学以及一般认知能力方面的研究结果。虽然其中部分数据的初步报告已经发表,但本专著的目的是呈现新的单变量、多变量和纵向分析,系统地考察所有年龄段整个样本在所有测量指标上,针对低极端情况(障碍)和整个样本(能力)的遗传和环境影响。尽管这些年英语、数学和科学的内容有重大变化,但在7岁、9岁和10岁时,它们的遗传度同样很高,共享环境影响适中。我们得出了三个超出遗传度估计范畴的结论。第一,异常即正常:低表现是在整个正态分布中起作用的相同遗传和环境影响的数量极端情况。第二,连续性源于遗传,变化来自环境:纵向分析表明,年龄间的稳定性主要由遗传介导,而环境则导致年龄间的变化。第三,基因具有普遍性,环境具有特殊性:多变量分析表明,基因在很大程度上促成了三个领域内部及之间以及与一般认知能力在表现上的相似性,而环境则导致了表现上的差异。这些结论对教育、儿童发展以及分子遗传学和神经科学都具有深远影响。