Monkul E Serap, Matsuo Koji, Nicoletti Mark A, Dierschke Nicole, Hatch John P, Dalwani Manish, Brambilla Paolo, Caetano Sheila, Sassi Roberto B, Mallinger Allan G, Soares Jair C
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Neurosci Lett. 2007 Dec 11;429(1):7-11. doi: 10.1016/j.neulet.2007.09.074. Epub 2007 Oct 10.
The objective of this study was to test the hypothesis that 4 weeks of lithium administration would be associated with changes in brain gray and white matter volumes in healthy individuals. Thirteen right-handed healthy volunteers (6 females, mean age=25.9+/-10.0 years) were studied. 3D SPGR MRIs (TR=25 ms, TE=5 ms, slice-thickness=1.5 mm) were acquired using a 1.5 T GE Signa Imaging System, at baseline and after 4 weeks of lithium administration at therapeutically relevant doses. Optimized voxel-based morphometry (VBM) analyses were conducted. Left and right dorsolateral prefrontal cortex and left anterior cingulate gray matter volumes increased significantly following lithium administration. Total white matter volume was increased, whereas total brain volume and total gray matter volume were not significantly changed following 4 weeks of lithium. Lithium treatment resulted in prefrontal regional gray matter volume increases in healthy volunteers, as well as increases in total white matter volume. Whether these changes are mediated by neurotrophic/neuroprotective or osmotic effects remains unknown.
对健康个体给予4周的锂治疗会导致脑灰质和白质体积发生变化。研究了13名右利手健康志愿者（6名女性，平均年龄=25.9±10.0岁）。使用1.5T GE Signa成像系统在基线时以及给予治疗相关剂量的锂4周后，采集3D SPGR MRI（TR=25毫秒，TE=5毫秒，层厚=1.5毫米）。进行了优化的基于体素的形态学测量（VBM）分析。给予锂后，左侧和右侧背外侧前额叶皮质以及左侧前扣带回的灰质体积显著增加。4周的锂治疗后，白质总体积增加，而脑总体积和灰质总体积没有显著变化。锂治疗导致健康志愿者前额叶区域灰质体积增加以及白质总体积增加。这些变化是否由神经营养/神经保护作用或渗透作用介导仍不清楚。
