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免疫疗法。

Immune therapies.

作者信息

Prabhala Rao H, Munshi Nikhil C

机构信息

Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Hematol Oncol Clin North Am. 2007 Dec;21(6):1217-30, x-xi. doi: 10.1016/j.hoc.2007.08.011.

DOI:10.1016/j.hoc.2007.08.011
PMID:17996595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2716007/
Abstract

Immune cells with specific functions and abilities are vital to cancer treatment prevention. Although there have been many accomplishments made in the areas of immunotherapy and immunobiology of myeloma, there are still many obstacles in the way of conceptualizing the interrelationships between immune cells and tumor cells. To provide better understanding of these concepts and to move toward improved therapies for myeloma, cell-based therapeutic approaches should be developed.

摘要

具有特定功能和能力的免疫细胞对癌症治疗预防至关重要。尽管在骨髓瘤的免疫治疗和免疫生物学领域已经取得了许多成就,但在理解免疫细胞与肿瘤细胞之间的相互关系方面仍存在许多障碍。为了更好地理解这些概念并朝着改进骨髓瘤治疗方法的方向发展,应开发基于细胞的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3455/2716007/22804c43c7c7/nihms35607f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3455/2716007/22804c43c7c7/nihms35607f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3455/2716007/22804c43c7c7/nihms35607f1.jpg

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1
Immune therapies.免疫疗法。
Hematol Oncol Clin North Am. 2007 Dec;21(6):1217-30, x-xi. doi: 10.1016/j.hoc.2007.08.011.
2
Dendritic cells in clinical trials for multiple myeloma.用于多发性骨髓瘤临床试验的树突状细胞。
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Production of myeloid dendritic cells (DC) pulsed with tumor-specific idiotype protein for vaccination of patients with multiple myeloma.制备用肿瘤特异性独特型蛋白脉冲处理的髓样树突状细胞(DC),用于多发性骨髓瘤患者的疫苗接种。
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引用本文的文献

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Targeting IL-17A in multiple myeloma: a potential novel therapeutic approach in myeloma.靶向白细胞介素-17A治疗多发性骨髓瘤:骨髓瘤一种潜在的新型治疗方法。
Leukemia. 2016 Feb;30(2):379-89. doi: 10.1038/leu.2015.228. Epub 2015 Aug 21.
2
Identification of human leucocyte antigen (HLA)-A*0201-restricted cytotoxic T lymphocyte epitopes derived from HLA-DOβ as a novel target for multiple myeloma.鉴定人白细胞抗原(HLA)-A*0201 限制性细胞毒性 T 淋巴细胞表位来源于 HLA-DOβ 作为多发性骨髓瘤的一个新靶点。
Br J Haematol. 2013 Nov;163(3):343-51. doi: 10.1111/bjh.12544. Epub 2013 Aug 30.
3
New strategies in the treatment of multiple myeloma.多发性骨髓瘤的治疗新策略。
Clin Cancer Res. 2013 Jul 1;19(13):3337-44. doi: 10.1158/1078-0432.CCR-12-1881. Epub 2013 Mar 20.

本文引用的文献

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Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061.支柱文章:转录因子Foxp3对调节性T细胞发育的控制。《科学》2003年。299卷:1057 - 1061页。
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Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.白细胞介素1β和6而非转化生长因子β对于产生白细胞介素17的人辅助性T细胞的分化至关重要。
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Host immune system gene targeting by a viral miRNA.病毒微小RNA对宿主免疫系统基因的靶向作用。
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6
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.产生白细胞介素-17的人类辅助性T记忆细胞的表面表型和抗原特异性
Nat Immunol. 2007 Jun;8(6):639-46. doi: 10.1038/ni1467. Epub 2007 May 7.
7
Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy.单克隆丙种球蛋白病患者对胚胎干细胞相关抗原SOX2的频繁且特异性免疫。
J Exp Med. 2007 Apr 16;204(4):831-40. doi: 10.1084/jem.20062387. Epub 2007 Mar 26.
8
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.Foxp3通过与AML1/Runx1相互作用来控制调节性T细胞的功能。
Nature. 2007 Apr 5;446(7136):685-9. doi: 10.1038/nature05673. Epub 2007 Mar 21.
9
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.通过信号转导和转录激活因子5(STAT5)的白细胞介素-2信号传导会抑制辅助性T细胞17的生成。
Immunity. 2007 Mar;26(3):371-81. doi: 10.1016/j.immuni.2007.02.009.
10
Dendritic cell function can be modulated through cooperative actions of TLR ligands and invariant NKT cells.树突状细胞的功能可通过Toll样受体(TLR)配体和不变自然杀伤T细胞的协同作用来调节。
J Immunol. 2007 Mar 1;178(5):2721-9. doi: 10.4049/jimmunol.178.5.2721.