（β-甲基-3H-）-苄青霉素和（β-甲基-3H）-6-氨基青霉烷酸的合成
Synthesis of (beta-methyl-3H-)-benzylpenicillin and (beta-methyl-3H)-6-aminopenicillanic acid.
作者信息
Meesschaert B, Adriaens P, Eyssen H
出版信息
J Antibiot (Tokyo). 1976 Apr;29(4):433-7. doi: 10.7164/antibiotics.29.433.
PMID:179970
Abstract
The synthesis of benzylpenicillin and 6-aminopenicillanic acid, labeled with tritium in the beta-methyl group, is described. Benzylpenicillin S-sulfoxide benzyl ester is refluxed in benzene and tritiated water and is successively debenzylated and deoxygenated to (beta-methyl-3H)-benzylpenicillin. Removal of the side chain with a bacterial acylase gives (beta-methyl-3H)-6-aminopenicillanic acid.
摘要
本文描述了在β-甲基上用氚标记的苄青霉素和6-氨基青霉烷酸的合成。苄青霉素S-亚砜苄酯在苯和氚化水中回流，依次进行脱苄基和脱氧反应，得到（β-甲基-³H）-苄青霉素。用细菌酰基转移酶去除侧链，得到（β-甲基-³H）-6-氨基青霉烷酸。
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