Kale Anvita, Joshi Sadhana, Naphade Nilesh, Sapkale Swati, Raju M S V K, Pillai Anilkumar, Nasrallah Henry, Mahadik Sahebarao P
Interactive Research School for Health Affairs, Bharati Vidyapeeth, Pune 411043, India.
Schizophr Res. 2008 Jan;98(1-3):295-301. doi: 10.1016/j.schres.2007.09.036. Epub 2007 Nov 7.
Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls matched for ethnicity, diet and life style. The plasma EPUFAs levels were similar in both groups. Among the EPUFAs enriched in the brain, predominantly docosahexaenoic acid (DHA) levels were lower in RBC (p=<0.01) whereas higher in CSF (p=<0.01) in male>female patients. This altered DHA metabolism may provide clues for neuropathology and treatment of schizophrenia.
精神分裂症患者体内必需多不饱和脂肪酸（EPUFAs）水平各异，这可能是由年龄、性别、种族、饮食、生活方式及治疗方法的不同所致。本研究检测了未接受过药物治疗的首发精神病患者以及在种族、饮食和生活方式上相匹配的正常对照者血浆、红细胞和脑脊液中的EPUFAs水平。两组的血浆EPUFAs水平相似。在大脑中富集的EPUFAs中，男性患者红细胞中的二十二碳六烯酸（DHA）水平显著低于女性（p<0.01），而脑脊液中的DHA水平则高于女性（p<0.01）。这种DHA代谢的改变可能为精神分裂症的神经病理学和治疗提供线索。
