Klein Barbara E K, Knudtson Michael D, Lee Kristine E, Reinke Jennifer O, Danforth Lorraine G, Wealti Angela M, Moore Emily, Klein Ronald
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA.
Ophthalmology. 2008 Jul;115(7):1203-8. doi: 10.1016/j.ophtha.2007.09.011. Epub 2007 Nov 12.
To investigate the association of use of vitamin, mineral, and nonvitamin nonmineral supplements with common age-related eye diseases.
Population-based prospective study with incidence data.
Subjects were participants in the Beaver Dam Eye Study who contributed data in 1988 to 1990 (n = 4926), 1993 to 1995 (n = 3722), 1998 to 2000 (n = 2962), and 2003 to 2005 (n = 2375).
Use of all medications and supplements were collected from study participants at each of 4 examinations. Intraocular pressure (IOP) measurement and fundus and lens photography were done at each visit. Visual field data are available only from baseline. Photographs of the lenses, retina, and discs were graded using standard protocols by trained graders.
Incidence of age-related cataracts, macular degeneration (AMD), and high IOP for one set of analyses and incidence of supplement use for the second set of analyses.
There was little evidence of any significant associations between supplement use and incident ocular outcomes except for a small protective effect for cortical cataracts by vitamins A and D, zinc, and multivitamins and increased odds of late AMD. Late AMD was associated with incident use of vitamins A, C, and E and zinc.
Age-related macular degeneration seems to precede use of vitamins A, C, and E and zinc. This may reflect advice by family, friends, and health care providers about the benefits of Age-Related Eye Disease Study-like supplements.
研究维生素、矿物质及非维生素非矿物质补充剂的使用与常见的年龄相关性眼病之间的关联。
基于人群的前瞻性研究，收集发病率数据。
受试者为比弗迪尔眼科研究的参与者，他们在1988年至1990年（n = 4926）、1993年至1995年（n = 3722）、1998年至2000年（n = 2962）以及2003年至2005年（n = 2375）期间提供了数据。
在4次检查中的每次检查时，收集研究参与者使用的所有药物和补充剂信息。每次就诊时均测量眼压（IOP）并进行眼底和晶状体照相。视野数据仅可从基线获得。由经过培训的分级人员使用标准方案对晶状体、视网膜和视盘的照片进行分级。
一组分析为年龄相关性白内障、黄斑变性（AMD）和高眼压的发病率，另一组分析为补充剂使用的发病率。
除了维生素A和D、锌及多种维生素对皮质性白内障有较小的保护作用以及晚期AMD的患病几率增加外，几乎没有证据表明补充剂使用与眼部疾病发病之间存在任何显著关联。晚期AMD与维生素A、C、E及锌的使用有关。
年龄相关性黄斑变性似乎先于维生素A、C、E及锌的使用。这可能反映了家人、朋友及医疗保健提供者关于年龄相关性眼病研究类补充剂益处的建议。
