（-）-奥基拉霉素的全合成。
Total synthesis of (-)-okilactomycin.
作者信息
Smith Amos B, Basu Kallol, Bosanac Todd
机构信息
Department of Chemistry, Laboratory for Research on the Structure of Matter, and Monell Chemical Senses Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
出版信息
J Am Chem Soc. 2007 Dec 5;129(48):14872-4. doi: 10.1021/ja077569l. Epub 2007 Nov 13.
PMID:17997560
Abstract
A highly convergent synthesis of (-)-okilactomycin is described. Key reactions of this synthesis include a strategy-level diastereoselective oxy-Cope rearrangement/oxidation sequence, a Petasis-Ferrier union/rearrangement tactic, and an efficient RCM reaction to construct the 13-membered macrocyclic ring.
摘要
描述了(-)-奥基拉霉素的一种高度收敛的合成方法。该合成的关键反应包括一个策略层面的非对映选择性氧杂-Cope重排/氧化序列、一个Petasis-Ferrier偶联/重排策略以及一个用于构建13元大环的高效RCM反应。
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