Saeed Sadaf, Munawar Saba, Ahmad Sajjad, Mansha Asim, Zahoor Ameer Fawad, Irfan Ali, Irfan Ahmad, Kotwica-Mojzych Katarzyna, Soroka Malgorzata, Głowacka Mariola, Mojzych Mariusz
Medicinal Chemistry Research Lab, Department of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan.
Department of Basic Sciences and Humanities, University of Engineering and Technology Lahore, Faisalabad Campus, Faisalabad 38000, Pakistan.
Molecules. 2023 Dec 10;28(24):8032. doi: 10.3390/molecules28248032.
The Petasis reaction, also called the Petasis Borono-Mannich reaction, is a multicomponent reaction that couples a carbonyl derivative, an amine and boronic acids to yield substituted amines. The reaction proceeds efficiently in the presence or absence of a specific catalyst and solvent. By employing this reaction, a diverse range of chiral derivatives can easily be obtained, including α-amino acids. A broad substrate scope, high yields, distinct functional group tolerance and the availability of diverse catalytic systems constitute key features of this reaction. In this review article, attention has been drawn toward the recently reported methodologies for executing the Petasis reaction to produce structurally simple to complex aryl/allyl amino scaffolds.
佩塔西斯反应，也称为佩塔西斯硼-曼尼希反应，是一种多组分反应，它将羰基衍生物、胺和硼酸偶联以生成取代胺。该反应在有或没有特定催化剂和溶剂的情况下都能高效进行。通过采用这种反应，可以轻松获得各种手性衍生物，包括α-氨基酸。广泛的底物范围、高产率、独特的官能团耐受性以及多种催化体系的可用性是该反应的关键特征。在这篇综述文章中，已关注到最近报道的用于进行佩塔西斯反应以生成结构简单至复杂的芳基/烯丙基氨基支架的方法。
