Giljohann David A, Seferos Dwight S, Patel Pinal C, Millstone Jill E, Rosi Nathaniel L, Mirkin Chad A
Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208-3113, USA.
Nano Lett. 2007 Dec;7(12):3818-21. doi: 10.1021/nl072471q. Epub 2007 Nov 13.
The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated with the particle.
对寡核苷酸修饰纳米颗粒的细胞内吞作用进行了研究。摄取取决于颗粒表面寡核苷酸负载的密度,密度越高,摄取量越大。高度功能化的纳米颗粒在其表面吸附大量蛋白质。在大量蛋白质与颗粒相关联的情况下,纳米颗粒的摄取量最大。