Cho Si Hyun, Oh Yoon Jin, Nam Anna, Kim Hye Yeon, Park Joo Hyun, Kim Jae Hoon, Park Ki Hyun, Cho Dong Je, Lee Byung Seok
Department of Obstetrics and Gynecology, Yongdong Severance Hospital, Yonsei University, College of Medicine, Dogok-dong, KangNam-gu, Seoul, Korea.
Am J Reprod Immunol. 2007 Dec;58(6):497-504. doi: 10.1111/j.1600-0897.2007.00535.x.
The aim of this study was to evaluate serum and urinary levels of vascular endothelial growth factors, tumor necrosis factor-alpha (TNF-alpha), and soluble fms-like tyrosine kinase (sFlt-1) in patients with endometriosis.
During surgery for pelvic pain, pelvic mass or infertility, serum and urine were collected. Of 70 patients, 46 had histology-proven endometriosis and 24 patients without endometriosis participated as controls.
Serum TNF-alpha levels and urinary sFlt-1 levels corrected for creatinine excretion were significantly increased in the endometriosis group (P=0.001 and P=0.011 respectively). Serum sFlt-1 levels and urinary sFlt-1 levels corrected for creatinine were significantly higher in patients with minimal-to-mild disease (P=0.014 and P=0.015 respectively), where serum TNF-alpha levels were increased in moderate-to-severe endometriosis (P<0.001).
The pathogenesis of minimal-to-mild endometriosis and moderate-to-severe endometriosis seems to be different. Increased sFlt-1 levels in serum and urine of minimal-to-mild disease indicate that sFlt-1 may have an important role in inhibiting angiogenic process of the disease.
本研究旨在评估子宫内膜异位症患者血清和尿液中血管内皮生长因子、肿瘤坏死因子-α（TNF-α）以及可溶性fms样酪氨酸激酶（sFlt-1）的水平。
在因盆腔疼痛、盆腔肿块或不孕进行手术期间，收集血清和尿液。70例患者中，46例经组织学证实为子宫内膜异位症，24例无子宫内膜异位症的患者作为对照。
子宫内膜异位症组经肌酐排泄校正后的血清TNF-α水平和尿液sFlt-1水平显著升高（分别为P = 0.001和P = 0.011）。轻度至中度疾病患者经肌酐校正后的血清sFlt-1水平和尿液sFlt-1水平显著更高（分别为P = 0.014和P = 0.015），而中重度子宫内膜异位症患者血清TNF-α水平升高（P < 0.）。
轻度至中度子宫内膜异位症和中重度子宫内膜异位症的发病机制似乎不同。轻度至中度疾病患者血清和尿液中sFlt-1水平升高表明sFlt-1可能在抑制该疾病的血管生成过程中起重要作用。
