Luo Min, He Yuan-Li, Peng Dong-Xian, Liu Mu-Biao, Chen Yan-Ying
Department of Obstetrics and Gynecology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Jun;30(3):304-6.
To evaluate the levels of tumor necrosis factor-alpha (TNF-alpha) and tumor necrosis factor-beta (TNF-beta) before and after conservative laparoscopic surgery in patients with endometriosis.
The levels of TNF-alpha and TNF-beta in the serum of both 82 patients with EMS and 68 controls were determined by ELISA.
The levels of TNF-alpha and TNF-beta in the serum of patients with EMS were significantly higher than those of the controls (P < 0.01), and they increased with the clinical terms ( P < 0.05). After clearance of endometrosis foci with laparoscopic conservative surgery, the TNF-alpha levels decreased significantly in EMS III - IV, and TNF-beta levels decreased significantly in EMS I - IV.
Measuring TNF-alpha and TNF-beta levels in the serum of patients with EMS may have important value in postoperative follow-up, surveillance and evaluation of the effectiveness of the surgery.
评估子宫内膜异位症患者保守性腹腔镜手术前后肿瘤坏死因子-α（TNF-α）和肿瘤坏死因子-β（TNF-β）的水平。
采用酶联免疫吸附测定法（ELISA）检测82例子宫内膜异位症患者（EMS）和68例对照者血清中TNF-α和TNF-β的水平。
EMS患者血清中TNF-α和TNF-β的水平显著高于对照组（P < 0.01），且随病情进展而升高（P < 0.05）。经腹腔镜保守手术清除子宫内膜异位病灶后，EMS III - IV期患者的TNF-α水平显著降低，EMS I - IV期患者的TNF-β水平显著降低。
检测EMS患者血清中TNF-α和TNF-β的水平可能对术后随访、监测及评估手术效果具有重要价值。
