Koumenis Constantinos, Bi Meixia, Ye Jiangbin, Feldman Douglas, Koong Albert C
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Methods Enzymol. 2007;435:275-93. doi: 10.1016/S0076-6879(07)35014-3.
Tumor hypoxia refers to the development of regions within solid tumors in which the oxygen concentration is lower (0-3%) compared to that in most normal tissues (4-9%) (Vaupel and Hockel, 2000). Considerable experimental and clinical evidence exists supporting the notion that hypoxia fundamentally alters the physiology of the tumor towards a more aggressive phenotype (Hockel and Vaupel, 2001). Therefore, delineating the mechanisms by which hypoxia affects tumor physiology at the cellular and molecular levels will be crucial for a better understanding of tumor development and metastasis and for designing better antitumor modalities.
肿瘤缺氧是指实体瘤内某些区域的氧浓度低于大多数正常组织（4%-9%）（氧浓度为0%-3%）（沃佩尔和霍克尔，2000年）。大量实验和临床证据支持以下观点：缺氧从根本上改变肿瘤的生理学，使其朝着更具侵袭性的表型发展（霍克尔和沃佩尔，2001年）。因此，阐明缺氧在细胞和分子水平上影响肿瘤生理学的机制，对于更好地理解肿瘤的发生发展和转移以及设计更好的抗肿瘤治疗方法至关重要。
