对12名接受左氧氟沙星治疗的儿童中耳积液和鼻咽部分离出的肺炎链球菌的特征及动态变化研究
Characterization and dynamics of middle ear fluid and nasopharyngeal isolates of Streptococcus pneumoniae from 12 children treated with levofloxacin.
作者信息
Davies Todd A, Leibovitz Eugene, Noel Gary J, McNeeley David F, Bush Karen, Dagan Ron
机构信息
Johnson & Johnson Pharmaceutical Research and Development, LLC, Room B225, 1000 Route 202, Raritan, NJ 08869, USA.
出版信息
Antimicrob Agents Chemother. 2008 Jan;52(1):378-81. doi: 10.1128/AAC.01068-07. Epub 2007 Nov 12.
Abstract
Children who had acute otitis media and were treated with levofloxacin were assessed for the emergence of fluoroquinolone-resistant Streptococcus pneumoniae. Nasopharynx cultures were obtained from patients at the entry to and during levofloxacin therapy. All nasopharynx isolates (n = 59) from 12 children were levofloxacin susceptible without parC/E or gyrA/B mutations. Pneumococcal nasopharynx persistence was not associated with levofloxacin resistance.
摘要
对患有急性中耳炎并接受左氧氟沙星治疗的儿童进行了耐氟喹诺酮肺炎链球菌出现情况的评估。在左氧氟沙星治疗开始时及治疗期间从患者处获取鼻咽部培养物。12名儿童的所有鼻咽部分离株（n = 59）对左氧氟沙星敏感，无parC/E或gyrA/B突变。肺炎链球菌在鼻咽部的持续存在与左氧氟沙星耐药性无关。
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