• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Characterization and dynamics of middle ear fluid and nasopharyngeal isolates of Streptococcus pneumoniae from 12 children treated with levofloxacin.对12名接受左氧氟沙星治疗的儿童中耳积液和鼻咽部分离出的肺炎链球菌的特征及动态变化研究
Antimicrob Agents Chemother. 2008 Jan;52(1):378-81. doi: 10.1128/AAC.01068-07. Epub 2007 Nov 12.
2
Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study.南非儿童中左氧氟沙星不敏感肺炎链球菌的出现及耐多药结核病的治疗：一项队列观察性监测研究
Lancet. 2008 Mar 29;371(9618):1108-13. doi: 10.1016/S0140-6736(08)60350-5. Epub 2008 Mar 21.
3
In vitro activities of levofloxacin and comparable agents against middle ear fluid, nasopharyngeal, and oropharyngeal pathogens obtained from Costa Rican children with recurrent otitis media or failing other antibiotic therapy.左氧氟沙星及同类药物对从患有复发性中耳炎或其他抗生素治疗失败的哥斯达黎加儿童中分离出的中耳积液、鼻咽和口咽病原体的体外活性。
Antimicrob Agents Chemother. 2005 Jul;49(7):3056-8. doi: 10.1128/AAC.49.7.3056-3058.2005.
4
Molecular characterization of emerging non-levofloxacin-susceptible pneumococci isolated from children in South Africa.从南非儿童中分离出的新出现的非左氧氟沙星敏感肺炎球菌的分子特征
J Clin Microbiol. 2009 May;47(5):1319-24. doi: 10.1128/JCM.02280-08. Epub 2009 Mar 4.
5
Dynamics of pneumococcal nasopharyngeal carriage in children with nonresponsive acute otitis media treated with two regimens of intramuscular ceftriaxone.两种肌内注射头孢曲松方案治疗无反应性急性中耳炎儿童的肺炎球菌鼻咽部携带动态变化
Pediatr Infect Dis J. 2002 Jul;21(7):642-7. doi: 10.1097/00006454-200207000-00008.
6
Predictive value of pneumococcal nasopharyngeal cultures for the assessment of nonresponsive acute otitis media in children.肺炎球菌鼻咽培养物对评估儿童无反应性急性中耳炎的预测价值。
Pediatr Infect Dis J. 2000 Apr;19(4):298-303. doi: 10.1097/00006454-200004000-00007.
7
Molecular epidemiology of fluoroquinolone resistance in invasive clinical isolates of Streptococcus pneumoniae in Seville.塞维利亚侵袭性临床分离肺炎链球菌中氟喹诺酮耐药的分子流行病学研究。
Enferm Infecc Microbiol Clin. 2012 Apr;30(4):180-3. doi: 10.1016/j.eimc.2011.10.006. Epub 2012 Feb 24.
8
Antimicrobial resistance of nasopharyngeal pneumococci from children from day-care centres and orphanages in Russia: results of a unique prospective multicentre study.俄罗斯日托中心和孤儿院儿童鼻咽部肺炎球菌的抗菌药物耐药性：一项独特的前瞻性多中心研究结果
Clin Microbiol Infect. 2006 Sep;12(9):853-66. doi: 10.1111/j.1469-0691.2006.01505.x.
9
Antibiotic resistance of Streptococcus pneumoniae in children with acute otitis media treatment failure.急性中耳炎治疗失败患儿中肺炎链球菌的抗生素耐药性
Int J Pediatr Otorhinolaryngol. 2015 Dec;79(12):2129-33. doi: 10.1016/j.ijporl.2015.09.030. Epub 2015 Sep 30.
10
Acute otitis media caused by Streptococcus pneumoniae in children's hospitals between 1994 and 1997.1994年至1997年间儿童医院中由肺炎链球菌引起的急性中耳炎。
Pediatr Infect Dis J. 2001 Jan;20(1):34-9. doi: 10.1097/00006454-200101000-00007.

引用本文的文献

1
Safety Concerns Surrounding Quinolone Use in Children.儿童使用喹诺酮类药物的安全性问题
J Clin Pharmacol. 2016 Sep;56(9):1060-75. doi: 10.1002/jcph.715. Epub 2016 Mar 28.

本文引用的文献

1
An open-label, double tympanocentesis study of levofloxacin therapy in children with, or at high risk for, recurrent or persistent acute otitis media.一项关于左氧氟沙星治疗复发性或持续性急性中耳炎患儿或高危患儿的开放标签、双次鼓膜穿刺研究。
Pediatr Infect Dis J. 2006 Dec;25(12):1102-9. doi: 10.1097/01.inf.0000246828.13834.f9.
2
Infrequent occurrence of single mutations in topoisomerase IV and DNA gyrase genes among US levofloxacin-susceptible clinical isolates of Streptococcus pneumoniae from nine institutions (1999-2003).在美国九个机构（1999 - 2003年）对左氧氟沙星敏感的肺炎链球菌临床分离株中，拓扑异构酶IV和DNA促旋酶基因单突变的发生率较低。
J Antimicrob Chemother. 2006 Mar;57(3):437-42. doi: 10.1093/jac/dki487. Epub 2006 Jan 23.
3
Nasopharyngeal carriage of Streptococcus pneumoniae at the completion of successful antibiotic treatment of acute otitis media predisposes to early clinical recurrence.急性中耳炎成功进行抗生素治疗结束时肺炎链球菌的鼻咽部携带易导致早期临床复发。
J Infect Dis. 2005 Jun 1;191(11):1869-75. doi: 10.1086/429918. Epub 2005 Apr 28.
4
Open label, multicenter study of gatifloxacin treatment of recurrent otitis media and acute otitis media treatment failure.
Pediatr Infect Dis J. 2003 Nov;22(11):949-56. doi: 10.1097/01.inf.0000095193.42502.d1.
5
Bacteriologic and clinical efficacy of oral gatifloxacin for the treatment of recurrent/nonresponsive acute otitis media: an open label, noncomparative, double tympanocentesis study.口服加替沙星治疗复发性/难治性急性中耳炎的细菌学及临床疗效：一项开放标签、非对照、双鼓膜穿刺研究
Pediatr Infect Dis J. 2003 Nov;22(11):943-9. doi: 10.1097/01.inf.0000095468.89866.14.
6
Cross-resistance, relatedness and allele analysis of fluoroquinolone-resistant US clinical isolates of Streptococcus pneumoniae (1998-2000).1998 - 2000年美国耐氟喹诺酮类肺炎链球菌临床分离株的交叉耐药性、亲缘关系及等位基因分析
J Antimicrob Chemother. 2003 Aug;52(2):168-75. doi: 10.1093/jac/dkg309. Epub 2003 Jul 1.
7
Antibiotic treatment in acute Otitis Media promotes superinfection with resistant Streptococcus pneumoniae carried before initiation of treatment.急性中耳炎的抗生素治疗会促使在治疗开始前携带的耐药肺炎链球菌发生二重感染。
J Infect Dis. 2001 Mar 15;183(6):880-6. doi: 10.1086/319250. Epub 2001 Feb 9.
8
Effects of amoxicillin/clavulanate or azithromycin on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae in children with acute otitis media.阿莫西林/克拉维酸或阿奇霉素对急性中耳炎患儿肺炎链球菌和流感嗜血杆菌鼻咽部携带情况的影响。
Clin Infect Dis. 2000 Oct;31(4):875-80. doi: 10.1086/318160. Epub 2000 Oct 25.
9
Dynamics of pneumococcal nasopharyngeal colonization during the first days of antibiotic treatment in pediatric patients.儿科患者抗生素治疗初期肺炎球菌鼻咽部定植的动态变化
Pediatr Infect Dis J. 1998 Oct;17(10):880-5. doi: 10.1097/00006454-199810000-00006.
10
Early eradication of pathogens from middle ear fluid during antibiotic treatment of acute otitis media is associated with improved clinical outcome.在急性中耳炎抗生素治疗期间，从中耳液中早期清除病原体与改善临床结局相关。
Pediatr Infect Dis J. 1998 Sep;17(9):776-82. doi: 10.1097/00006454-199809000-00005.

对12名接受左氧氟沙星治疗的儿童中耳积液和鼻咽部分离出的肺炎链球菌的特征及动态变化研究

Characterization and dynamics of middle ear fluid and nasopharyngeal isolates of Streptococcus pneumoniae from 12 children treated with levofloxacin.

作者信息

Davies Todd A, Leibovitz Eugene, Noel Gary J, McNeeley David F, Bush Karen, Dagan Ron

机构信息

Johnson & Johnson Pharmaceutical Research and Development, LLC, Room B225, 1000 Route 202, Raritan, NJ 08869, USA.

出版信息

Antimicrob Agents Chemother. 2008 Jan;52(1):378-81. doi: 10.1128/AAC.01068-07. Epub 2007 Nov 12.

DOI:10.1128/AAC.01068-07
PMID:17999965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2223889/
Abstract

Children who had acute otitis media and were treated with levofloxacin were assessed for the emergence of fluoroquinolone-resistant Streptococcus pneumoniae. Nasopharynx cultures were obtained from patients at the entry to and during levofloxacin therapy. All nasopharynx isolates (n = 59) from 12 children were levofloxacin susceptible without parC/E or gyrA/B mutations. Pneumococcal nasopharynx persistence was not associated with levofloxacin resistance.

摘要

对患有急性中耳炎并接受左氧氟沙星治疗的儿童进行了耐氟喹诺酮肺炎链球菌出现情况的评估。在左氧氟沙星治疗开始时及治疗期间从患者处获取鼻咽部培养物。12名儿童的所有鼻咽部分离株（n = 59）对左氧氟沙星敏感，无parC/E或gyrA/B突变。肺炎链球菌在鼻咽部的持续存在与左氧氟沙星耐药性无关。