Boldsen Jesper L
Max Planck Institute for Demographic Research, Rostock, Germany.
Am J Phys Anthropol. 2008 Mar;135(3):301-10. doi: 10.1002/ajpa.20744.
Leprosy was a well-recognized and dreaded disease in medieval Europe (5th-15th century AD). It is reported to have reached Germany with the Roman invasion. A much larger fraction than previously assumed appears to have been affected by leprosy in the medieval period. This article estimates the frequency (i.e., the prevalence at death) of leprosy among adult people buried in the Lauchheim early medieval cemetery. Seven different dichotomous osteological lesions indicative of leprosy are analyzed, and it is possible to score at least one of these conditions on 110 adult skeletons (aged 15 or more). The scores were transformed to a statistic--lambda (lambda)--indicating the likelihood that the person to whom the skeleton belonged suffered from leprosy. The analyses indicate that 16% (95% confidence interval: 9-23%) of adult people in Lauchheim died with osteological signs of leprosy. Leprosy was significantly more prevalent among men than women. The lambda statistic indicates that people who died with signs of leprosy did not differ in the distribution of age at death from those who did not have such signs. Some of the leprosy-related lesions had a statistically significant nonrandom dispersal on the cemetery; but there is no clear pattern to this and the significant results could be easily attributed to a type-1 error in the statistical analysis.
麻风病在中世纪欧洲(公元5世纪至15世纪)是一种广为人知且令人恐惧的疾病。据报道,它随着罗马人的入侵传入德国。在中世纪,受麻风病影响的人数比例似乎比之前设想的要大得多。本文估计了埋葬在劳希姆早期中世纪墓地的成年人中麻风病的发病频率(即死亡时的患病率)。分析了七种不同的表明麻风病的二分法骨骼病变,在110具成年骨骼(年龄15岁及以上)上至少可以对其中一种情况进行评分。这些分数被转换为一个统计量——λ(lambda),表明骨骼所属之人患麻风病的可能性。分析表明,劳希姆16%(95%置信区间:9 - 23%)的成年人死于有麻风病的骨骼迹象。麻风病在男性中的患病率明显高于女性。λ统计量表明,死于有麻风病迹象的人与没有此类迹象的人在死亡年龄分布上没有差异。一些与麻风病相关的病变在墓地上有统计学上显著的非随机分布;但对此并没有明确的模式,而且这些显著结果很容易归因于统计分析中的I型错误。