Jackman Hayley, Marsden Stephen P, Shapland Peter, Barrett Simon
School of Chemistry, University of Leeds, Leeds LS2 9JT, United Kingdom.
Org Lett. 2007 Dec 6;9(25):5179-82. doi: 10.1021/ol702225r. Epub 2007 Nov 15.
The use of 2H NMR spectroscopy as a tool for the analysis of enantiomeric purity is reported. Enantiopure isotopically chiral substrates bearing a monodeuterated methylene unit were prepared; introduction of an additional asymmetric center leads to diastereomers which can be distinguished by 2H NMR on a standard spectrometer. The assays allow for simple semiquantitative analysis of asymmetric transformations.
报道了使用2H核磁共振光谱作为分析对映体纯度的工具。制备了带有单氘代亚甲基单元的对映体纯的同位素手性底物；引入额外的不对称中心会产生非对映异构体，这些非对映异构体可以在标准光谱仪上通过2H核磁共振进行区分。这些分析方法允许对不对称转化进行简单的半定量分析。
