Shimizu Mamoru, Sodeoka Mikiko
RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, 351-0198, Japan.
Org Lett. 2007 Dec 6;9(25):5231-4. doi: 10.1021/ol7024108. Epub 2007 Nov 15.
A convenient, rapid, and efficient method for the preparation of carbamates from amines with 1-alkoxycarbonyl-3-nitro-1,2,4-triazole transfer reagents is reported. Reactions of newly synthesized stable crystalline reagents with alkyl amines were completed in a few minutes without any additional base, and highly pure carbamates were obtained without chromatographic purification. These highly active reagents are also useful for the selective protection of nucleobases and preparation of carbonates and thiocarbonates.
报道了一种用1-烷氧羰基-3-硝基-1,2,4-三唑转移试剂从胺制备氨基甲酸酯的简便、快速且高效的方法。新合成的稳定结晶试剂与烷基胺的反应在几分钟内即可完成，无需任何额外的碱，并且无需色谱纯化就能获得高纯度的氨基甲酸酯。这些高活性试剂还可用于选择性保护核碱基以及制备碳酸酯和硫代碳酸酯。
