通过钯催化的溴代烷基胺的C-C/C-N偶联反应合成并苯稠合的N-杂环化合物。
Synthesis of benzannulated N-heterocycles by a palladium-catalyzed C-C/C-N coupling of bromoalkylamines.
作者信息
Thansandote Praew, Raemy Manuel, Rudolph Alena, Lautens Mark
机构信息
Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S 3H6.
出版信息
Org Lett. 2007 Dec 6;9(25):5255-8. doi: 10.1021/ol702472u. Epub 2007 Nov 15.
PMID:18001046
Abstract
A palladium-catalyzed domino intermolecular alkylation/intramolecular amination of functionalized aryl iodides represents a new strategy for the synthesis of benzannulated N-heterocycles, affording functionalized indolines and tetrahydroquinolines from simple precursors.
摘要
钯催化的官能化芳基碘化物的分子间多米诺烷基化/分子内胺化反应代表了一种合成苯并稠合N-杂环的新策略，可从简单前体得到官能化的二氢吲哚和四氢喹啉。
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