Fusco Alfredo, Fedele Monica
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli "Federico II", via Pansini, 5, 80131, Naples, Italy.
Nat Rev Cancer. 2007 Dec;7(12):899-910. doi: 10.1038/nrc2271.
The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure and thereby regulate the transcription of several genes by either enhancing or suppressing transcription factors. This protein family is implicated, through different mechanisms, in both benign and malignant neoplasias. Rearrangements of HMGA genes are a feature of most benign human mesenchymal tumours. Conversely, unrearranged HMGA overexpression is a feature of malignant tumours and is also causally related to neoplastic cell transformation. Here, we focus on the role of the HMGA proteins in human neoplastic diseases, the mechanisms by which they contribute to carcinogenesis, and therapeutic strategies based on targeting HMGA proteins.
高迁移率族A（HMGA）非组蛋白染色质蛋白可改变染色质结构，从而通过增强或抑制转录因子来调控多个基因的转录。该蛋白家族通过不同机制与良性和恶性肿瘤形成均有关联。HMGA基因重排是大多数人类良性间充质肿瘤的一个特征。相反，未重排的HMGA过表达是恶性肿瘤的一个特征，并且也与肿瘤细胞转化存在因果关系。在此，我们重点关注HMGA蛋白在人类肿瘤性疾病中的作用、它们促成肿瘤发生的机制以及基于靶向HMGA蛋白的治疗策略。
