Pastrana Jiménez J I, Catalina Romero C, García Diéguez N, Lopez-Ibor Aliño J J
Psychiatry and Clinical Psychology Unit, Dirección Médica de Contingencias Comunes de los Servicios Centrales de Ibermutuamur, Madrid, Spain.
Actas Esp Psiquiatr. 2007 Nov-Dec;35(6):351-8.
Pharmacological treatment of traumarelated mobidity has neither the efficacy nor specificity desired. Thus, several attempts have been made to add new drugs to the usual treatments, in this case with propranolol and hypnotic drugs.
We offered this treatment to the victims of the March 11, 2004 terrorism attack who were attended within the first week of this attack for psychiatric reasons (n=21) and who also fulfilled criteria for acute stress disorder (ASD) (n=15) and had no contraindications for the treatment (n=3). Trauma intensity was measured with Horowitz impact of events scale (IES). Significant clinical data were collected.
Propranolol treatment was associated with clinical remission of target symptoms in 63.6 % of the cases, partial response in 27.3 % and no response in 9.1%. Hypnotic treatment was also associated with clinical remission in 61.5 % and partial response in 38.5 %. Statistically significant correlations were found at the beginning for IES with disability, and after the first month with the propranolol and hypnotic responses.
Propranolol and hypnotic treatments are useful in the decrease of ASD symptoms. IES is very useful to predict disability as well as poor response to propranolol or hypnotic drugs. More studies are needed to confirm the data obtained in our sample.
创伤相关疾病的药物治疗既没有达到预期的疗效，也缺乏特异性。因此，人们尝试在常规治疗中添加新药，在本研究中使用了普萘洛尔和催眠药物。
我们为2004年3月11日恐怖袭击的受害者提供了这种治疗，这些受害者在袭击后的第一周因精神原因前来就诊（n = 21），同时符合急性应激障碍（ASD）的标准（n = 15）且无治疗禁忌（n = 3）。使用霍洛维茨事件影响量表（IES）测量创伤强度。收集了重要的临床数据。
普萘洛尔治疗使63.6%的病例目标症状临床缓解，27.3%部分缓解，9.1%无反应。催眠治疗也使61.5%临床缓解，38.5%部分缓解。在开始时，IES与残疾程度存在统计学显著相关性，在第一个月后，与普萘洛尔和催眠药物的反应存在相关性。
普萘洛尔和催眠治疗有助于减轻ASD症状。IES对于预测残疾以及对普萘洛尔或催眠药物反应不佳非常有用。需要更多研究来证实我们样本中获得的数据。
