Leonard Ralph H, Smith Lynn R, Garland Glenn E, Tiwana Karen K, Zaidel Lynette A, Pugh George, Lin Nora C
Department of Diagnostic Sciences and General Dentistry, UNC School of Dentistry, Chapel Hill, NC 27599-7450, USA.
J Esthet Restor Dent. 2007;19(6):355-64; discussion 365-6. doi: 10.1111/j.1708-8240.2007.00136.x.
The objective of this nightguard vital bleaching (NGVB) study was to compare tooth sensitivity (TS), gingival irritation (GIr), and other side effects, as well as patients' perceptions during tooth bleaching, from treatment with experimental 5 and 7% hydrogen peroxide (HP) bleaching solutions with those of a commercially available 10% carbamide peroxide (CP) product.
Sixty-one participants completed the study wearing a scalloped maxillary treatment tray without reservoirs with the different concentrations of bleaching gels for 30 minutes twice a day for 7 days. Parameters evaluated were changes in gingival index (GI), nonmarginal gingival index, nongingival oral mucosal index, and tooth vitality. Participants were seen pretreatment, after 7 treatment days, and 1 week post-treatment. A daily log form to record TS and GIr was completed by each participant as well as a sensitivity questionnaire at each appointment. Additionally, at 10 months post-treatment, a questionnaire was sent to the participants concerning TS and GIr relative to the treatment process.
Data from end-of-treatment questionnaires, daily log forms, and clinical examination revealed a statistical difference (p < or = 0.05) in the patients' ranking of and days of TS and GIr between group S (7% HP) and group T (10% CP, control group) at the end of active treatment. There also existed a statistical clinical change in the GI levels for groups R and S compared with the control group T. There was no statistical difference (p > 0.05) in any of the parameters evaluated among the three products at 7 days or 10 months post-treatment.
Participants in group S reported significantly more TS, GIr, and days of each compared with the control. There also existed a significant clinical change in the GI levels for groups R and S compared with the control group T. There was no significant difference among the three products at 7 days post-treatment. After ending treatment, TS/GIr was resolved in 2 to 3 days and did not recur during the 10 months post-treatment.
The experimental HP bleaching solutions, as described in this study, can be used in NGVB with no long-term side effects as evaluated in this study for up to 10 months post-treatment.
本夜间护齿漂白（NGVB）研究的目的是比较使用实验性5%和7%过氧化氢（HP）漂白溶液与市售10%过氧化脲（CP）产品进行牙齿漂白时的牙齿敏感度（TS）、牙龈刺激（GIr）及其他副作用，以及患者在牙齿漂白过程中的感受。
61名参与者完成了该研究，他们佩戴无储液槽的扇形上颌治疗托盘，每天两次，每次30分钟，使用不同浓度的漂白凝胶，持续7天。评估的参数包括牙龈指数（GI）、非边缘牙龈指数、非牙龈口腔黏膜指数和牙齿活力的变化。在治疗前、治疗7天后和治疗后1周对参与者进行检查。每位参与者填写每日日志表以记录TS和GIr，并在每次就诊时填写一份敏感度问卷。此外，在治疗后10个月，向参与者发送一份关于与治疗过程相关的TS和GIr的问卷。
治疗结束时问卷、每日日志表和临床检查的数据显示，在积极治疗结束时，S组（7%HP）和T组（10%CP，对照组）患者在TS和GIr的排名及天数方面存在统计学差异（p≤0.05）。与对照组T相比，R组和S组的GI水平也存在统计学临床变化。在治疗后7天或10个月，三种产品评估的任何参数均无统计学差异（p>0.05）。
与对照组相比，S组参与者报告的TS、GIr及各自的天数明显更多。与对照组T相比，R组和S组的GI水平也存在显著临床变化。治疗后7天，三种产品之间无显著差异。治疗结束后，TS/GIr在2至3天内消退，在治疗后10个月内未复发。
如本研究所述，实验性HP漂白溶液可用于NGVB，在本研究评估的长达治疗后10个月的时间内无长期副作用。
