Arai Y-C P, Kandatsu N, Ito H, Sato Y, Satake Y, Mizutani M, Ushida T, Komatsu T
Multidisciplinary Pain Center, Aichi Medical University, Aichi, Japan.
Acta Anaesthesiol Scand. 2008 Feb;52(2):285-8. doi: 10.1111/j.1399-6576.2007.01527.x. Epub 2007 Nov 14.
The parents of the children who undergo surgery experience stress during the pre-anesthetic period. Such stress influences the mental status of their children, thereby inducing their pre-anesthetic anxiety and problematic behavior at emergence. Recently, measurement of salivary biomarkers was evaluated as stress biomarkers. Especially, alpha-amylase is utilized as an excellent index for psychological stress. In the present study, we tested whether salivary amylase activity of mothers before the surgery of their children correlates with the peri-operative children's behaviors.
A total of 22 pairs of mothers and children were analyzed. Maternal salivary amylase activity was evaluated at the entrance of the operation room. The children underwent minor plastic surgery under general anesthesia, and induction and emergence behaviors were assessed.
The higher the maternal salivary amylase activity, the severer the children's induction anxiety (r(s)=-0.667, n=22, P<0.0001), and the higher the maternal amylase activity, the severer the children's emergence agitation (r(s)=0.705, n=22, P<0.0001).
Induction and emergence behaviors of children undergoing general anesthesia significantly correlated with their respective maternal salivary amylase activity during the pre-anesthetic period.
接受手术患儿的家长在麻醉前阶段会经历压力。这种压力会影响其子女的精神状态，从而导致其麻醉前焦虑以及苏醒期的问题行为。最近，唾液生物标志物的测量被评估为压力生物标志物。特别是，α-淀粉酶被用作心理压力的一个优良指标。在本研究中，我们测试了患儿手术前母亲的唾液淀粉酶活性是否与围手术期患儿的行为相关。
共分析了22对母婴。在手术室入口处评估母亲的唾液淀粉酶活性。患儿在全身麻醉下接受小型整形手术，并评估诱导期和苏醒期的行为。
母亲唾液淀粉酶活性越高，患儿诱导期焦虑越严重（r(s)= -0.667，n = 22，P < 0.0001），母亲淀粉酶活性越高，患儿苏醒期躁动越严重（r(s)= 0.705，n = 22，P < 0.0001）。
接受全身麻醉患儿的诱导期和苏醒期行为与麻醉前阶段各自母亲的唾液淀粉酶活性显著相关。
