Revelli Alberto, Rovei Valentina, Racca Cinzia, Gianetti Andrea, Massobrio Marco
Reproductive Medicine and IVF Unit, Department of Gynecological and Obstetrical Sciences, University of Turin, S. Anna Hospital, Turin, Italy.
Obstet Gynecol Surv. 2007 Dec;62(12):803-11. doi: 10.1097/01.ogx.0000290348.29697.61.
Fertility preservation in young girls affected by malignancies has got growing relevance in the last decade due to the improved survival chance of these patients after oncostatic treatments. Most studies have focused on preserving ovarian follicles and avoiding premature ovarian failure, whereas only a few have evaluated the effects exerted by radiotherapy and chemotherapy on the uterus. It is self-evident that fertility preservation after oncostatic therapies must include the maintenance of a functional uterus, and a certain degree of uterine damage must be considered when estimating reproductive prognosis in previously treated, childhood cancer survivors.
Obstetricians & Gynecologists, Family Physicians.
After completion of this article, the reader should be able to recall the growing number of children who survive oncostatic treatments, explain the possible effects on future reproductive endeavors, and summarize the possible ways to preserve fertility.
在过去十年中，由于接受肿瘤抑制治疗后这些患者的生存机会有所改善，年轻女性癌症患者的生育力保存变得越来越重要。大多数研究都集中在保存卵巢卵泡和避免卵巢早衰，而只有少数研究评估了放疗和化疗对子宫的影响。不言而喻，肿瘤抑制治疗后的生育力保存必须包括维持子宫功能，在评估先前接受治疗的儿童癌症幸存者的生殖预后时，必须考虑一定程度的子宫损伤。
妇产科医生、家庭医生。
阅读本文后，读者应能够回忆起接受肿瘤抑制治疗后存活的儿童数量不断增加，解释对未来生殖努力可能产生的影响，并总结保存生育力的可能方法。
