Lawrenz B, Henes M, Neunhoeffer E, Fehm T, Lang P, Schwarze C P
IVF-Department, Women's University Hospital Tuebingen, Germany.
Klin Padiatr. 2011 May;223(3):126-30. doi: 10.1055/s-0031-1275292. Epub 2011 Apr 6.
There has been a significant improvement in survival rates over the last decade as a result of advances in the treatment of cancer in children. One of the consequences of chemotherapy may be damage to the ovarian function, which can lead to loss of fertility. Methods of fertility protection have been developed for adult women as a result of advances in reproductive medicine, which make the option of becoming pregnant after surviving cancer realistic. However, only some of the methods can be used in prepubescent girls and adolescents. In addition, a higher number of miscarriages and premature births have been found in women who underwent pelvic radiotherapy during childhood or adolescence and the children were more commonly growth retarded. The effects of cancer treatment on the ovarian function and later fertility should be discussed at the start of treatment.
在过去十年中，由于儿童癌症治疗取得进展，存活率有了显著提高。化疗的后果之一可能是卵巢功能受损，这可能导致生育能力丧失。由于生殖医学的进步，已经为成年女性开发了生育保护方法，这使得癌症幸存者怀孕成为现实选择。然而，只有一些方法可用于青春期前女孩和青少年。此外，在儿童期或青春期接受盆腔放疗的女性中，流产和早产的发生率更高，并且这些女性的孩子更常见生长发育迟缓。应在治疗开始时讨论癌症治疗对卵巢功能和后期生育能力的影响。
