Rytkönen Anne, Holden David W
Department of Infectious Diseases, Centre for Molecular Microbiology and Infection, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, United Kingdom.
Cell Host Microbe. 2007 Mar 15;1(1):13-22. doi: 10.1016/j.chom.2007.02.003.
Ubiquitination and deubiquitination regulate several essential cellular processes such as protein degradation, cell-cycle progression, signaling, and DNA repair. Given the importance of these processes, it is not surprising that many microbes have developed the means to interfere with different stages of ubiquitin pathways to promote their survival and replication. This review focuses on virulence proteins of bacterial pathogens that mediate these effects and summarizes our current understanding of their actions.
泛素化和去泛素化调节多种重要的细胞过程，如蛋白质降解、细胞周期进程、信号传导和DNA修复。鉴于这些过程的重要性，许多微生物已发展出干扰泛素途径不同阶段以促进其生存和复制的手段，这并不奇怪。本综述重点关注介导这些效应的细菌病原体的毒力蛋白，并总结了我们目前对其作用的理解。
