Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University , Suzhou, Jiangsu, China.
Department of Clinical Laboratory, Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine , Zhangjiagang, Jiangsu, China.
Infect Immun. 2023 Oct 17;91(10):e0028323. doi: 10.1128/iai.00283-23. Epub 2023 Sep 19.
Bacteria frequently interfere with the post-translational modifications of host cells to facilitate their survival and growth after invasion. SUMOylation, a reversible post-translational modification process, plays an important role in biological life activities. In addition to being critical to host cell metabolism and survival, SUMOylation also regulates gene expression and cell signal transmission. Moreover, SUMOylation in eukaryotic cells can be used by a variety of bacterial pathogens to advance bacterial invasion. In this minireview, we focused on the role and mechanism of host SUMOylation in the pathogenesis of six important clinical bacterial pathogens (, , Typhimurium, , and ). Taken together, this review provided new insights for understanding the unique pathogen-host interaction based on host SUMOylation and provided a novel perspective on the development of new strategies to combat bacterial infections in the future.
细菌经常干扰宿主细胞的翻译后修饰，以促进入侵后其生存和生长。SUMOylation 是一种可逆的翻译后修饰过程，在生物生命活动中发挥着重要作用。除了对宿主细胞代谢和生存至关重要外，SUMOylation 还调节基因表达和细胞信号转导。此外，真核细胞中的 SUMOylation 可被多种细菌病原体利用，以促进细菌入侵。在这篇综述中，我们重点关注宿主 SUMOylation 在六种重要临床细菌病原体（、、、、和）发病机制中的作用和机制。综上所述，本综述为基于宿主 SUMOylation 理解独特的病原体-宿主相互作用提供了新的见解，并为未来开发对抗细菌感染的新策略提供了新的视角。
