Gunn John S, Richards Susan M
Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA.
Cell Host Microbe. 2007 May 17;1(3):163-5. doi: 10.1016/j.chom.2007.05.001.
Two-component regulatory systems are commonly used by bacteria to sense and respond to their environment. In Molecular Cell, Prost et al. describe how low pH activates the Salmonella PhoQ sensor kinase, building on their previous demonstration that the PhoQ periplasmic domain senses magnesium and antimicrobial peptides. These findings are likely to be broadly applicable for understanding how bacteria recognize and transduce the multiple signals characteristic of their complex extracellular environments.
双组分调节系统是细菌常用的感知和响应环境的方式。在《分子细胞》杂志上，普罗斯特等人描述了低pH值如何激活沙门氏菌PhoQ传感激酶，这是基于他们之前的研究，即PhoQ周质结构域可感知镁和抗菌肽。这些发现可能广泛适用于理解细菌如何识别和转导其复杂细胞外环境的多种特征信号。
