Schumacher Paul, Dineen Sean, Barnett Carlton, Fleming Jason, Anthony Thomas
Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, MC-9155, Dallas, TX 75390-9155, USA.
Am J Surg. 2007 Dec;194(6):827-31; discussion 831-2. doi: 10.1016/j.amjsurg.2007.08.030.
Lymph node metastases are the most important predictor of survival in non-stage IV colon cancer. Recent studies of gastric cancer have shown a prognostic significance of a lymph node ratio (number of positive nodes divided by total number harvested). Our goal was to determine whether a lymph node ratio (LNR) would predict disease-free survival (DFS) and overall survival (OS) in a tertiary care Veterans Affairs medical center.
A retrospective review of a prospectively collected database of colon cancer patients was performed to determine the effect of LNR on DFS and OS. A cohort of 232 patients with non-stage IV colon cancer was eligible for analysis. Survival curves were constructed using the Kaplan-Meier method.
For all patients, a LNR of .08 was identified as a breakpoint for predicting OS and DFS. Specific analysis of stage III patients revealed that a LNR of .18 was predictive of DFS.
This study showed the prognostic significance of ratio-based staging for colon cancer and may aid in future staging systems.
淋巴结转移是非IV期结肠癌生存的最重要预测指标。近期对胃癌的研究显示了淋巴结比率（阳性淋巴结数除以获取的淋巴结总数）的预后意义。我们的目标是确定在一家三级医疗退伍军人事务医疗中心，淋巴结比率（LNR）是否能预测无病生存期（DFS）和总生存期（OS）。
对前瞻性收集的结肠癌患者数据库进行回顾性分析，以确定LNR对DFS和OS的影响。232例非IV期结肠癌患者队列符合分析条件。采用Kaplan-Meier法构建生存曲线。
对所有患者而言，LNR为0.08被确定为预测OS和DFS的分界点。对III期患者的具体分析显示，LNR为0.18可预测DFS。
本研究显示了基于比率分期对结肠癌的预后意义，可能有助于未来的分期系统。
