来自拟分枝孢镰刀菌的两种新的单端孢霉烯族毒素。

Two new trichothecenes from Fusarium sporotrichioides.

作者信息

Bekele E, Rottinghaus A A, Rottinghaus G E, Casper H H, Fort D M, Barnes C L, Tempesta M S

机构信息

Veterinary Medical Diagnostic Laboratory, University of Missouri, Columbia 65211.

出版信息

J Nat Prod. 1991 Sep-Oct;54(5):1303-8. doi: 10.1021/np50077a011.

DOI:10.1021/np50077a011

PMID:1800633

Abstract

Two new trichothecenes, 8-n-pentanoylneosolaniol and 8-n-hexanoylneosolaniol, were isolated from corn grits cultured with Fusarium sporotrichioides. The structures of these compounds were elucidated using gc-ms, nmr, X-ray crystallography, and other spectroscopic techniques. Seven known trichothecenes were also isolated, and the relative cytotoxicity of these nine trichothecenes in cultured baby hamster kidney (BHK-21) cells was determined.

摘要

从用拟枝孢镰刀菌培养的玉米粗粉中分离出两种新的单端孢霉烯族毒素，8-正戊酰新茄病镰刀菌烯醇和8-正己酰新茄病镰刀菌烯醇。使用气相色谱-质谱联用仪、核磁共振、X射线晶体学和其他光谱技术对这些化合物的结构进行了阐明。还分离出了七种已知的单端孢霉烯族毒素，并测定了这九种单端孢霉烯族毒素在培养的幼仓鼠肾（BHK-21）细胞中的相对细胞毒性。