Morel O, Chagnaud S, Laperrelle J, Clément D, Malartic C, Akerman G, Tulpin L, Sitbon M, Barranger E
Service de Gynécologie-Obstétrique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris (AP-HP), 2, Rue Ambroise-Paré, 75010, Paris, France.
Gynecol Obstet Fertil. 2007 Nov;35(11):1095-104. doi: 10.1016/j.gyobfe.2007.07.036. Epub 2007 Nov 19.
Parvovirus B19 infection during pregnancy is at risk of adverse fetal outcome. The risk is increased if maternal infection occurs during the first two trimesters, but may also happen during the third trimester. Adverse first and third trimester fetal outcome were recently highlighted by polymerase chain reaction (PCR) viral DNA detection. Parvovirus does not seem to be a significant teratogen. Infection during pregnancy can cause severe fetal anaemia and nonimmune hydrops fetalis. Cardiac tropism of the virus can cause myocarditis and aggravate the cardiac failure. Follow up of in utero anaemia is based upon the middle cerebral artery peak systolic flow velocity evaluation and treatment is based upon cordocentesis transfusion.
孕期感染细小病毒B19有导致不良胎儿结局的风险。如果孕妇在前两孕期发生感染，风险会增加，但在第三孕期也可能发生。最近通过聚合酶链反应（PCR）检测病毒DNA凸显了孕早期和孕晚期不良的胎儿结局。细小病毒似乎不是一种重要的致畸原。孕期感染可导致严重的胎儿贫血和非免疫性胎儿水肿。该病毒的心肌嗜性可引起心肌炎并加重心力衰竭。宫内贫血的随访基于大脑中动脉收缩期峰值流速评估，治疗则基于脐静脉穿刺输血。
