Moenner Michel, Pluquet Olivier, Bouchecareilh Marion, Chevet Eric
Institut National de la Sante et de la Recherche Medicale, E0113, Bordeaux, France.
Cancer Res. 2007 Nov 15;67(22):10631-4. doi: 10.1158/0008-5472.CAN-07-1705.
The endoplasmic reticulum (ER) has emerged as a major site of cellular homeostasis regulation, particularly in the unfolded protein response, which is being found to play a major role in cancer and many other diseases. Here, we address ER-mediated signaling and regulations in the context of environmental challenges in cancer, such as hypoxia, angiogenesis, and chemotherapeutic resistance, and we discuss how ER-resident molecular machines become deregulated and involved in cancer-related pathology. Further exploration of how the ER senses, signals, and adapts to stress may redefine and deepen our understanding of its functions in cancer pathobiology.
内质网（ER）已成为细胞稳态调节的主要场所，尤其是在未折叠蛋白反应中，该反应在癌症和许多其他疾病中发挥着重要作用。在此，我们探讨在癌症相关的环境挑战（如缺氧、血管生成和化疗耐药）背景下内质网介导的信号传导和调控，并且讨论内质网驻留分子机器如何失调并参与癌症相关病理过程。进一步探索内质网如何感知、发出信号并适应应激，可能会重新定义并加深我们对其在癌症病理生物学中功能的理解。
