Basseri Sana, Austin Richard C
Department of Medicine, McMaster University, St. Joseph's Healthcare and the Henderson Research Centre, Hamilton, ON, Canada.
Dev Cell. 2008 Dec;15(6):795-6. doi: 10.1016/j.devcel.2008.11.013.
Endoplasmic reticulum (ER) stress and activation of the unfolded protein response have been linked to many human disorders, including obesity, type 2 diabetes, and cancer. In this issue of Developmental Cell,Rutkowski et al. (2008) show that unresolved ER stress contributes to metabolic dysfunction and hepatic steatosis.
内质网（ER）应激与未折叠蛋白反应的激活与许多人类疾病有关，包括肥胖症、2型糖尿病和癌症。在本期《发育细胞》杂志中，鲁特科夫斯基等人（2008年）表明，未解决的内质网应激会导致代谢功能障碍和肝脂肪变性。
