赫苏肽A关键前体的合成
Synthesis of the key precursor of Hirsutellide A.
作者信息
Xu Yanjie, Duan Xuemin, Li Meiling, Jiang Liqin, Zhao Guangle, Meng Yi, Chen Ligong
机构信息
College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin, 300072, PR China.
出版信息
Molecules. 2005 Jan 31;10(1):259-64. doi: 10.3390/10010259.
Abstract
Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.
摘要
六肽缩酚酸肽2是赫素肽A（1）的前体，以N - Boc - 甲基甘氨酸为原料，通过分别使用二环己基碳二亚胺（DCC）、O-（7-氮杂苯并三唑-1-基）-N，N，N'，N'-四甲基脲六氟磷酸盐（HATU）和双（2-氧代-3-恶唑烷基）次膦酰氯（BOP-Cl）的三步偶联反应，以45%的总收率合成得到。
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