赫苏肽A，一种从昆虫病原真菌小林赫苏菌中分离得到的新型抗分枝杆菌环六肽缩酚酸肽。

Hirsutellide A, a new antimycobacterial cyclohexadepsipeptide from the entomopathogenic fungus Hirsutella kobayasii.

作者信息

Vongvanich Namphung, Kittakoop Prasat, Isaka Masahiko, Trakulnaleamsai Srisuda, Vimuttipong Saovaluk, Tanticharoen Morakot, Thebtaranonth Yodhathai

机构信息

Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

出版信息

J Nat Prod. 2002 Sep;65(9):1346-8. doi: 10.1021/np020055+.

DOI:10.1021/np020055+

PMID:12350163

Abstract

A new cyclohexadepsipeptide, named hirsutellide A (1), was isolated from a cell extract of the entomopathogenic fungus Hirsutella kobayasii BCC 1660. The structure of 1 was elucidated by analyses of spectroscopic data, and its absolute stereochemistry was addressed by the use of Marfey's method. Hirsutellide A (1) exhibited antimycobacterial and antimalarial activities, but was inactive toward the Vero cell line (at 50 microg/mL).

摘要

从昆虫病原真菌小笠原被毛孢Hirsutella kobayasii BCC 1660的细胞提取物中分离出一种新的环六肽缩肽，命名为被毛孢素A（1）。通过光谱数据分析阐明了1的结构，并使用马尔菲法确定了其绝对立体化学。被毛孢素A（1）具有抗分枝杆菌和抗疟活性，但对Vero细胞系无活性（50微克/毫升）。