Vongvanich Namphung, Kittakoop Prasat, Isaka Masahiko, Trakulnaleamsai Srisuda, Vimuttipong Saovaluk, Tanticharoen Morakot, Thebtaranonth Yodhathai
Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
J Nat Prod. 2002 Sep;65(9):1346-8. doi: 10.1021/np020055+.
A new cyclohexadepsipeptide, named hirsutellide A (1), was isolated from a cell extract of the entomopathogenic fungus Hirsutella kobayasii BCC 1660. The structure of 1 was elucidated by analyses of spectroscopic data, and its absolute stereochemistry was addressed by the use of Marfey's method. Hirsutellide A (1) exhibited antimycobacterial and antimalarial activities, but was inactive toward the Vero cell line (at 50 microg/mL).
从昆虫病原真菌小笠原被毛孢Hirsutella kobayasii BCC 1660的细胞提取物中分离出一种新的环六肽缩肽，命名为被毛孢素A（1）。通过光谱数据分析阐明了1的结构，并使用马尔菲法确定了其绝对立体化学。被毛孢素A（1）具有抗分枝杆菌和抗疟活性，但对Vero细胞系无活性（50微克/毫升）。
