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4-氨基-4,5-二氢-1H-1,2,4-三唑-5-酮及其异吲哚酮-3-亚胺衍生物的合成

Synthesis of 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones and their isatin-3-imine derivatives.

作者信息

Kahveci Bahittin

机构信息

Department of Chemistry, Rize Faculty of Arts and Science, Karadeniz Technical University, 53100, Rize, Turkey.

出版信息

Molecules. 2005 Feb 28;10(2):376-82. doi: 10.3390/10020376.

DOI:10.3390/10020376
PMID:18007308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6147540/
Abstract

Iminoester hydrochlorides 1 have been synthesized. These compounds were then converted into ester ethoxycarbonyl hydrazones 2, from which in turn a new series of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones, 3, was then prepared. Finally a set of isatin imine derivatives 4 was obtained from the reaction of compounds 3 with isatin. The structures of all the new synthesized compounds were confirmed by elemental analyses, IR, (1)H-NMR and (13)C-NMR spectra.

摘要

已合成盐酸亚胺酯1。然后将这些化合物转化为酯乙氧羰基腙2,进而由其制备了一系列新的取代4-氨基-4,5-二氢-1H-1,2,4-三唑-5-酮3。最后,通过化合物3与异吲哚酮的反应得到了一组异吲哚酮亚胺衍生物4。所有新合成化合物的结构均通过元素分析、红外光谱、(1)H-NMR和(13)C-NMR光谱得以确证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c9/6147540/5997b01fbdf9/molecules-10-00376-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c9/6147540/5997b01fbdf9/molecules-10-00376-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c9/6147540/5997b01fbdf9/molecules-10-00376-g001.jpg

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