某些4,5-二氢-1H-1,2,4-三唑-5-酮的合成及其抗菌活性
Synthesis and antibacterial activities of some 4,5-dihydro-1H-1,2,4-triazol-5-ones.
作者信息
Yüksek H, Demirbaş A, Ikizler A, Johansson C B, Celik C, Ikizler A A
机构信息
Department of Chemistry, Karadeniz Technical University, Trabzon, Turkey.
出版信息
Arzneimittelforschung. 1997 Apr;47(4):405-9.
PMID:9150862
Abstract
Twenty-one new 1-methyl- and 1-ethyl-3,4-disubstituted-4,5-dihydro- 1H-1,2,4-triazol-5-ones were synthesized and characterised by elemental analysis, 1H-NMR and IR spectra. These new and 16 recently reported derivatives of 4,5-dihydro-1H-1,2,4-triazol-5-one ring were screened for their antibacterial activities.
摘要
合成了21种新的1-甲基和1-乙基-3,4-二取代-4,5-二氢-1H-1,2,4-三唑-5-酮，并通过元素分析、1H-NMR和IR光谱对其进行了表征。对这些新的以及最近报道的16种4,5-二氢-1H-1,2,4-三唑-5-酮环衍生物进行了抗菌活性筛选。
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