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5,6,7,8-四氢嘧啶并[4,5-b]喹啉衍生物的简便合成

Facile synthesis of 5, 6, 7, 8-tetrahydropyrimido [4, 5-b]-quinoline derivatives.

作者信息

Elkholy Yehya Mahmud, Morsy Mohamed Abdelhamed

机构信息

Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt.

出版信息

Molecules. 2006 Nov 17;11(11):890-903. doi: 10.3390/11110890.

DOI:10.3390/11110890
PMID:18007394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6148637/
Abstract

2-Amino-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile (3) was synthesized by treating cyclohexanone (1) with 2-benzylidenemalononitrile (2) in the presence of ammonium acetate. The reactivity of compound 3 towards dimethylformamide dimethyl acetal (DMF-DMA), carbon disulfide, urea, thiourea, formamide, formic acid, acetyl chloride and isothiocyanate were studied. In addition, the antimicrobial activity of some selected derivatives is reported.

摘要

通过在乙酸铵存在下用2-亚苄基丙二腈（2）处理环己酮（1）合成了2-氨基-4-苯基-5,6,7,8-四氢喹啉-3-腈（3）。研究了化合物3对二甲基甲酰胺二甲基缩醛（DMF-DMA）、二硫化碳、尿素、硫脲、甲酰胺、甲酸、乙酰氯和异硫氰酸酯的反应活性。此外，还报道了一些选定衍生物的抗菌活性。