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嘧啶并[4,5-b]喹啉的合成及其抗癌特性

Synthesis and anticancer properties of pyrimido[4,5-b]quinolines.

作者信息

Długosz A, Duś D

机构信息

Department of Organic Chemistry, University of Medicine, Faculty of Pharmacy, Grodzka, Poland.

出版信息

Farmaco. 1996 May;51(5):367-74.

PMID:8767847
Abstract

The synthesis and antitumor properties of pyrimido[4,5-b]quinolines have been described starting from 4-arylamino-5-carboxy-2-hydroxy-6-methylpyrimidines by reaction with PPA or POCl3. The reduced pyrimidoquinolines and derivatives with alkylating function have also been obtained.

摘要

从4-芳基氨基-5-羧基-2-羟基-6-甲基嘧啶出发，通过与多聚磷酸（PPA）或三氯氧磷（POCl3）反应，已对嘧啶并[4,5-b]喹啉的合成及其抗肿瘤特性进行了描述。还获得了还原型嘧啶并喹啉以及具有烷基化功能的衍生物。

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