Tang Lijun, Zhang Shufen, Yang Jinzong, Gao Wentao, Cui Jian, Zhuang Tianyu
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116012, PR China.
Molecules. 2004 Sep 30;9(10):842-8. doi: 10.3390/91000842.
A novel approach to the synthesis of 6-amino-7-hydroxyflavone (1) is described. Reaction in acetone of 2',4'-dihydroxy-5'-nitroacetophenone and benzoyl chloride in the presence of potassium carbonate affords 3-benzoyl-7-hydroxy-6-nitroflavone, which is cleaved in 5% ethanolic potassium hydroxide to give 1-(2,4-dihydroxy-5-nitrophenyl)-3- phenyl-1,3-propanedione. The 1,3-diketone thus formed is then transformed into 7-hydroxy- 6-nitroflavone, followed by reduction to afford the title compound.
描述了一种合成6-氨基-7-羟基黄酮（1）的新方法。在碳酸钾存在下，2',4'-二羟基-5'-硝基苯乙酮与苯甲酰氯在丙酮中反应得到3-苯甲酰基-7-羟基-6-硝基黄酮，该化合物在5%乙醇氢氧化钾中裂解得到1-(2,4-二羟基-5-硝基苯基)-3-苯基-1,3-丙二酮。由此形成的1,3-二酮随后转化为7-羟基-6-硝基黄酮，接着还原得到标题化合物。
