Rice-Evans C A, Miller N J, Paganga G
Division of Biochemistry and Molecular Biology, UMDS-Guy's Hospital, London, UK.
Free Radic Biol Med. 1996;20(7):933-56. doi: 10.1016/0891-5849(95)02227-9.
The recent explosion of interest in the bioactivity of the flavonoids of higher plants is due, at least in part, to the potential health benefits of these polyphenolic components of major dietary constituents. This review article discusses the biological properties of the flavonoids and focuses on the relationship between their antioxidant activity, as hydrogen donating free radical scavengers, and their chemical structures. This culminates in a proposed hierarchy of antioxidant activity in the aqueous phase. The cumulative findings concerning structure-antioxidant activity relationships in the lipophilic phase derive from studies on fatty acids, liposomes, and low-density lipoproteins; the factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.
近期人们对高等植物黄酮类化合物生物活性的兴趣激增，至少部分原因在于这些主要膳食成分中的多酚类成分对健康具有潜在益处。这篇综述文章讨论了黄酮类化合物的生物学特性，并着重探讨了它们作为氢供体自由基清除剂的抗氧化活性与其化学结构之间的关系。这最终形成了一个关于水相中抗氧化活性的拟议等级体系。关于亲脂相中结构 - 抗氧化活性关系的累积研究结果来自对脂肪酸、脂质体和低密度脂蛋白的研究；讨论了不同类多酚在增强其抗氧化能力方面的影响因素，并支持这样的观点，即黄酮类化合物的分配系数及其与相关自由基的反应速率决定了其在亲脂相中的抗氧化活性。
