Felix Nathan J, Allen Paul M
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Nat Rev Immunol. 2007 Dec;7(12):942-53. doi: 10.1038/nri2200.
T-cell alloreactivity is a well-established phenomenon, but its molecular basis has remained enigmatic. Although there are differences between T-cell recognition of conventional and allogeneic antigens, it has become increasingly clear that they share many similarities. Recent insights into the specificity of the T-cell receptor (TCR) for peptide and the seeming intrinsic affinity of the TCR for the surface of the MHC molecule have provided a better understanding of how the TCR and peptide-MHC complexes interact. Here, we highlight the similarities and differences between conventional and allogeneic recognition of TCR-peptide-MHC complexes, and discuss how our view of allorecognitionhas changed, as well as the implications for TCR specificity and T-cell development.
T细胞同种异体反应性是一种已被充分证实的现象，但其分子基础一直不明。尽管T细胞对传统抗原和同种异体抗原的识别存在差异，但越来越明显的是，它们有许多相似之处。最近对T细胞受体（TCR）对肽的特异性以及TCR对MHC分子表面看似内在亲和力的深入了解，使人们对TCR与肽-MHC复合物如何相互作用有了更好的理解。在这里，我们强调了TCR-肽-MHC复合物的传统识别与同种异体识别之间的异同，并讨论了我们对同种异体识别的看法是如何改变的，以及对TCR特异性和T细胞发育的影响。
