Stella F, Bucken-Gobbi L T, Gobbi S, Sant'Ana-Simões C
Instituto de Biociências, Universidade Estadual Paulista UNESP, Bela Vista, Sao Paulo, Brazil.
Rev Neurol. 2007;45(10):594-8.
Complex relations between brain and psychopathology have attracted the interest of researchers, aiming to clarify the neurobiological mechanisms of depression in Parkinson's disease, obviously in addiction to mental features.
The association of motor impairment and decline of personal autonomy with severity of depressive symptoms was the hypothesis of the present study. Aiming to check this hypothesis, the objective of this study consisted in investigating relationships between the severity of depressive symptoms and motor characteristics of Parkinson's disease.
Thirty patients (53 to 80 year-old) with medical diagnosis of idiopathic Parkinson's disease in initial clinic stages were studied. The Unified Parkinson's Disease Rating Scale, Hoehn-Yahr Scale, and Schwab & England Scale were used to assess the clinic signs and symptoms. The depressive symptoms were identified by complete anamnesis, examination of mental condition, and the Hamilton Rating Scale for Depression and the Anxiety and Depression Scale. Statistical analysis was performed by Pearson's correlation and multiple regression analysis.
A significant correlation of severity of depression symptoms with disease stage (p < 0.02), with motor signs (p < 0.008), and with functional performance (p < 0.007) was found.
There was significant association between motor impairment and severity of depressive symptoms, and between depression and early disease onset or prolonged duration of Parkinson's disease.
大脑与精神病理学之间的复杂关系吸引了研究人员的兴趣，他们旨在阐明帕金森病中抑郁症的神经生物学机制，显然这不仅仅局限于精神特征。
本研究的假设是运动功能障碍和个人自主性下降与抑郁症状的严重程度相关。为了验证这一假设，本研究的目的在于调查帕金森病抑郁症状的严重程度与运动特征之间的关系。
对30例年龄在53至80岁之间、处于临床初期且医学诊断为特发性帕金森病的患者进行了研究。采用统一帕金森病评定量表、霍恩-雅尔分级量表和施瓦布-英格兰量表来评估临床体征和症状。通过完整的病史采集、精神状况检查、汉密尔顿抑郁评定量表以及焦虑抑郁量表来识别抑郁症状。采用皮尔逊相关性分析和多元回归分析进行统计分析。
发现抑郁症状的严重程度与疾病分期（p < 0.02）、运动体征（p < 0.008）以及功能表现（p < 0.007）之间存在显著相关性。
运动功能障碍与抑郁症状的严重程度之间存在显著关联，抑郁与帕金森病的早期发病或病程延长之间也存在显著关联。
