Palmer E A, Flynn J T, Hardy R J, Phelps D L, Phillips C L, Schaffer D B, Tung B
Department of Ophthalmology, Oregon Health Sciences University, Portland.
Ophthalmology. 1991 Nov;98(11):1628-40. doi: 10.1016/s0161-6420(91)32074-8.
In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, 65.8% of the infants developed ROP to some degree; 81.6% for infants of less than 1000 g birth weight. As expected, ROP incidence and severity were higher in lower birth weight and gestational age categories. Black infants appeared less susceptible to ROP, of all severity categories, than nonblack infants. The timing of retinal vascular events correlated more closely with postconceptional age than with postnatal age, implicating the level of maturity more than postnatal environmental influences in governing the timing of these vascular events. These results include the current incidence of various severity stages of ROP found in the United States and provide new insight into the development of ROP.
在早产儿视网膜病变冷冻治疗多中心试验中，4099名出生体重小于1251克的婴儿从4至6周龄开始接受序贯眼科检查，以监测早产儿视网膜病变的发病率和病程。总体而言，65.8%的婴儿在某种程度上发生了早产儿视网膜病变；出生体重小于1000克的婴儿中这一比例为81.6%。正如预期的那样，出生体重和胎龄较低的类别中，早产儿视网膜病变的发病率和严重程度更高。在所有严重程度类别中，黑人婴儿似乎比非黑人婴儿更不易患早产儿视网膜病变。视网膜血管事件的发生时间与孕龄的相关性比与出生后年龄的相关性更密切，这表明在控制这些血管事件的发生时间方面，成熟水平比出生后的环境影响更为重要。这些结果包括在美国发现的早产儿视网膜病变各种严重程度阶段的当前发病率，并为早产儿视网膜病变的发展提供了新的见解。
