Department of Ophthalmology, Oregon Health Sciences University, Portland.
Department of Ophthalmology, Bascom Palmer Eye Institute, Miami.
Ophthalmology. 2020 Apr;127(4S):S84-S96. doi: 10.1016/j.ophtha.2020.01.034.
In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, 65.8% of the infants developed ROP to some degree; 81.6% for infants of less than 1000 g birth weight. As expected, ROP incidence and severity were higher in lower birth weight and gestational age categories. Black infants appeared less susceptible to ROP, of all severity categories, than nonblack infants. The timing of retinal vascular events correlated more closely with postconceptional age than with postnatal age, implicating the level of maturity more than postnatal environmental influences in governing the timing of these vascular events. These results include the current incidence of various severity stages of ROP found in the United States and provide new. insight into the development of ROP.
在早产儿视网膜病变（ROP）冷冻治疗多中心试验中，4099 名出生体重低于 1251 克的婴儿接受了连续的眼科检查，从出生后 4 至 6 周开始，以监测 ROP 的发生率和病程。总体而言，65.8%的婴儿出现了某种程度的 ROP；出生体重低于 1000 克的婴儿中，这一比例为 81.6%。如预期的那样，较低出生体重和胎龄组的 ROP 发生率和严重程度更高。在所有严重程度类别中，黑人婴儿比非黑人婴儿似乎对 ROP 的易感性较低。视网膜血管事件的发生时间与胎龄后时间的相关性比与出生后时间的相关性更密切，这表明在控制这些血管事件的发生时间方面，成熟度水平比出生后环境影响更为重要。这些结果包括了目前在美国发现的各种严重程度阶段的 ROP 的发生率，并为 ROP 的发展提供了新的见解。
