Dewasmes G, Duchamp C, Bothorel B, Candas V
Laboratoire de Physiologie et de Psychologie Environnementales, Institut National de Recherche et de Sécurité, UMR 32, Strasbourg, France.
Physiol Behav. 1991 Sep;50(3):537-41. doi: 10.1016/0031-9384(91)90542-v.
Species which do not enter torpor during fasting and which were efficiently able to spare their body proteins during the first two phases of fasting (which are commonly comprised of 3 successive phases) also increase their daily amount of slow-wave sleep (SWS) during the first two phases. Since in fasting animals the ability to spare proteins was reported to be improved when they were previously fed with a diet enriched with glycerol, it was supposed that, after such a diet, food-deprived rats would increase their daily quota of SWS. In addition, the tolerance to food deprivation, defined as the time elapsed to reach the end of phase II, should also be improved since this tolerance is known to be critically modulated by protein utilization. The daily proportions of wakefulness (W), SWS and paradoxical sleep (PS) were thus studied in Wistar rats after 16 weeks of feeding (i.e., when they were 27 weeks old) with an enriched glycerol diet. These daily W and sleep state proportions were then evaluated until the middle of fasting phase II (MII), i.e., when protein catabolism in the rat appears to be at its lowest level. The rats were able to tolerate more than 5 weeks of food deprivation, which represented an increase of 123% of the fasting tolerance previously reported in rats of the same age but which were fed normally before fasting onset. At MII the daily proportion of SWS was significantly (vs. fed state, p less than 0.01) increased (due to an increase in the daily mean episode duration), at the expense of W (due to a lowering in the daily occurrence of W episodes).(ABSTRACT TRUNCATED AT 250 WORDS)
在禁食期间不进入蛰伏状态、且在前两个禁食阶段（通常由连续三个阶段组成）能够有效节省身体蛋白质的物种，在这前两个阶段中其每日慢波睡眠（SWS）量也会增加。由于据报道，禁食动物在之前喂食富含甘油的饮食后，节省蛋白质的能力会得到改善，因此推测，在食用这种饮食后，食物剥夺的大鼠会增加其每日SWS配额。此外，对食物剥夺的耐受性（定义为达到第二阶段结束所经过的时间）也应得到改善，因为已知这种耐受性受到蛋白质利用的关键调节。因此，对16周龄（即27周大）的Wistar大鼠喂食富含甘油的饮食后，研究了它们清醒（W）、SWS和异相睡眠（PS）的每日比例。然后评估这些每日W和睡眠状态比例，直到禁食第二阶段中期（MII），即大鼠的蛋白质分解代谢似乎处于最低水平时。这些大鼠能够耐受超过5周的食物剥夺，这比之前报道的同年龄但在禁食开始前正常喂食的大鼠的禁食耐受性增加了123%。在MII时，SWS的每日比例显著增加（与喂食状态相比，p小于0.01）（由于每日平均发作持续时间增加），而W的比例则下降（由于W发作的每日发生率降低）。（摘要截短于250字）
